![]() ![]() ![]() After 10 days of taking clonidine, the nightmares had completely ceased. Within 3 days of starting clonidine, she reported a reduction in nightmares. In an attempt to reduce her recurring nightmares, the patient was prescribed clonidine 0.1 mg to take at night. Although bupropion improved her depressive symptoms more than other medications, she was sufficiently distressed by the dreams to inquire about stopping the medication. She continued to respond favorably to treatment with bupropion, and her depressive symptoms improved substantially. The nightmares were violent in nature and felt unusually real to the patient. Within a few days of initiating bupropion, her depressive symptoms started improving however, she also reported experiencing recurring nightmares and vivid dreams. Different medications were discussed with the patient, and, eventually, she was prescribed bupropion sustained-release 100-mg tablets due to her preference. The medications were ineffective in treating her symptoms, and she was tapered off escitalopram. She had a history of major depressive disorder for the past 4 years. 1 We describe, to our knowledge, the first case in which clonidine, an α-2 adrenergic agonist, was used to treat bupropion-induced nightmares.Ī 15-year-old girl with a history of anxiety and depression was prescribed escitalopram and lamotrigine to treat symptoms of depression. Bupropion, an antidepressant, is a norepinephrine dopamine reuptake inhibitor that potentially impacts sleep architecture by increasing REM sleep and density. Nightmares may be triggered by many factors including stress, anxiety, trauma, sleep deprivation, medications, and substance use. Nightmares, disturbing dreams that can distress and wake people from sleep, commonly occur during rapid eye movement (REM) sleep. Meghna Mathews a Nikhil Mathews a Faraz Jamal, BS a and Andrea Papa-Molter, DO a Bupropion-Induced Nightmares Treated With Clonidine
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